New signings Arno Botha, Mike Haley and Neil Cronin will make their PRO14 starting debuts for Munster, while Joey Carbery is set to make his debut in red if sprung off the bench.
Academy and Ireland 7s player Shane Daly is another making his debut as he joins Haley and Darren Sweetnam in the back three.
The pre-season centre combination of Rory Scannell and Dan Goggin remains unchanged for the tournament opener.
Neil Cronin, who last featured in the competition as a replacement in March 2015, partners up with JJ Hanrahan in the half backs.
In the front-row returning international prop John Ryan makes his first appearance of the season as he scrums down next to Mike Sherry and Dave Kilcoyne.
Captain Billy Holland and Jean Kleyn continue their partnership in the second-row with Dave O’Callaghan, Tommy O’Donnell and Botha forming the back-row.
Included in the replacements are Rhys Marshall and Stephen Archer who are in line to make first appearances of the season, with Archer overcoming the pec injury he sustained against Edinburgh in May.
After impressing in the pre-season campaign Academy back-row Gavin Coombes is included in his first Guinness PRO14 squad.
Meanwhile, the Cheetahs will be led by flanker Oupa Mohoje on Saturday.
Benhard Janse van Rensburg, Tian Schoeman, Luan de Bruin, JP du Preez, Walt Steenkamp, Aidon Davis and Ryno Eksteen will all make their PRO14 debuts.
Prediction: Munster by 16
Munster: 15 Mike Haley, 14 Darren Sweetnam, 13 Dan Goggin, 12 Rory Scannell, 11 Shane Daly, 10 JJ Hanrahan, 9 Neil Cronin, 8 Arno Botha, 7 Tommy O’Donnell, 6 Dave O’Callaghan, 5 Billy Holland (c), 4 Jean Kleyn, 3 John Ryan, 2 Mike Sherry, 1 Dave Kilcoyne
Replacements: 16 Rhys Marshall, 17 Brian Scott, 18 Stephen Archer, 19 Darren O’Shea, 20 Gavin Coombes, 21 James Hart, 22 Joey Carbery, 23 Sammy Arnold
Cheetahs: 15 Malcolm Jaer, 14 Rabz Maxwane, 13 Benhard Janse van Rensburg, 12 Nico Lee, 11 William Small-Smith, 10 Tian Schoeman, 9 Shaun Venter, 8 Jasper Wiese, 7 Oupa Mohoje (c), 6 Junior Pokomela, 5 JP du Preez, 4 Justin Basson, 3 Luan de Bruin, 2 Jacques du Toit, 1 Ox Nche
Replacements: 16 Joseph Dweba, 17 Charles Marais, 18 Aranos Coetzee, 19 Walt Steenkamp, 20 Aidon Davis, 21 Tian Meyer, 22 Ernst Stapelberg, 23 Ryno Eksteen