Warren Gatland made 14 changes to his starting line-up for their final test match this weekend against the Springboks.
Liam Williams will start at fifteen while Halfpenny has been ruled out due to concussion.
This is Gatland strongest side that was available and they will want to make a clean sweep in this November test series when they take on the Boks.
On the wings we have North and Adams to make up the back three with Davies and Anscombe at nine and ten.
In the midfield Parkes and Jonathan will continue their partnership.
Nicky Smith, Ken Owens and Tomas Francis are again named in the front-row with Adam Beard lining up alongside captain Alun Wyn Jones in the second row.
Dan Lydiate, Justin Tipuric and Ross Moriarty pack down in the back-row again.
“We want to end the campaign with a big performance against a very good South African side.” Gatland said to the media
Wales: 15 Liam Williams, 14 George North, 13 Jonathan Davies, 12 Hadleigh Parkes, 11 Josh Adams, 10 Gareth Anscombe, 9 Gareth Davies, 8 Ross Moriarty, 7 Justin Tipuric, 6 Dan Lydiate, 5 Alun Wyn Jones (c), 4 Adam Beard, 3 Tomas Francis, 2 Ken Owens, 1 Nicky Smith
Replacements: 16 Elliot Dee, 17 Rob Evans, 18 Dillon Lewis, 19 Cory Hill, 20 Ellis Jenkins, 21 Tomos Williams, 22 Dan Biggar, 23 Owen Watkin