The Waratahs will host the Reds on Saturday and coach Daryl Gibson has named a powerful team for the clash.
The Waratahs had a bye last week after coming away with a win against the Sunwolves in round 2, so they have one win and one lost so far this season.
The Reds are still without a win so far this season and this has become a very important match for them.
Adam Ashley-Cooper is back to full fitness after coming off the bench in Round Two, he’ll be joining Karmichael Hunt in the midfield.
Kurtley Beale will moving to full-back, with Folau moving to wing.
The Reds looked like a much improved side this year and they will be out to get that first win of the season.
“We are facing our oldest rival this week and we want to put out the strongest team we can,” Gibson said.
“The Reds are a very competitive unit, we saw that last weekend and saw that in their first game. We know what we’re in for.
“We know how important these derbies are from a conference standing, so there is plenty to play for.”
The Reds coach Brad Thorn made five changes to his side for this weekend match.
Duncan Paia’aua will replaces Jordan Petaia in the backline after the dynamic centre suffered a season-ending foot injury against the Crusaders last week.
Paia’aua will partner captain Samu Kerevi in the midfield.
Former Waratah, Bryce Hegarty has been named at flyhalf, while Isaac Lucas will make his first Super Rugby start at nine.
Up front, JP Smith and Scott Higginbotham will start at loosehead prop and number eight respectively.
There are also four changes to the Reds interchange with Angus Scott-Young and Hamish Stewart both named on the bench.
Reds head coach Brad Thorn said: “No matter what code or sport, Queensland v New South Wales are always good games. It’s a historic rivalry and I know our men will wear the maroon jersey with pride.
This is going to be a massive clash on Saturday at the SCG.
Prediction: We going for a Reds upset, Reds by 9
Waratahs: 15 Kurtley Beale, 14 Israel Folau, 13 Adam Ashley-Cooper, 12 Karmichael Hunt, 11 Curtis Rona, 10 Bernard Foley, 9 Jake Gordon, 8 Jack Dempsey, 7 Michael Hooper (captain), 6 Ned Hanigan, 5 Rob Simmons, 4 Jed Holloway, 3 Sekope Kepu, 2 Damien Fitzpatrick, 1 Harry Johnson-Holmes
Replacements: 16 Tatafu Polota-Nau, 17 Rory O’Connor, 18 Chris Talakai, 19 Lachlan Swinton, 20 Will Miller, 21 Mitch Short, 22 Mack Mason, 23 Alex Newsome
Reds: 15 Isaac Lucas, 14 Chris Feauai-Sautia, 13 Samu Kerevi (captain), 12 Duncan Paia’aua, 11 Sefa Naivalu, 10 Bryce Hegarty, 9 Moses Sorovi, 8 Scott Higginbotham, 7 Liam Wright, 6 Lukhan Salakaia-Loto, 5 Harry Hockings, 4 Izack Rodda, 3 Taniela Tupou, 2 Brandon Paenga-Amosa, 1 JP Smith
Replacements: 16 Alex Mafi, 17 Harry Hooper, 18 Ruan Smith, 19 Caleb Timu, 20 Angus Scott-Young, 21 Tate McDermott, 22 Hamish Stewart, 23 Jack Hardy.