Centre Dan Kriel and hooker Chad Solomon have flown out to join the DHL Stormers in Australia ahead of their final tour match against the Rebels on Friday.
Outside back SP Marais and lock Chris van Zyl have both flown back to Cape Town after picking up injuries against the Reds in Brisbane.
Marais has a hip flexor injury, while Van Zyl has been ruled out for at least six weeks due to a back injury.
Captain Siya Kolisi has also returned home as he is being rested this weekend.
Kriel and Solomon will join the squad in Brisbane ahead of the final tour game against the Rebels, which kicks off at 11h45 SA time on Friday in Melbourne.